Philadelphia University + Thomas Jefferson University

Bray, Paul F.

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Paul F. Bray, MD

Contact Dr. Bray

1015 Walnut Street
Suite 324
Philadelphia, PA 19107

(215) 955-8544
(215) 955-9170 fax

Research and Clinical Interests

Dr. Bray's laboratory studies the role of platelets in cardiovascular disease, and disorders of bleeding and excessive blood clotting. His major areas of investigation include: (1) The role of platelets in arterial thrombosis, with the identification and functional characterization of platelet risk factors and their impact on cardiovascular therapy. He studies how genetic variations in platelet adhesive molecules affect both the clinical and platelet phenotypes. (2) Identification of novel genes and gene products involved in platelet reactivity using genome scan and platelet RNA expression array approaches. (3) Studies on gender differences and hormonal effects on platelet function and thrombosis. (4) Pharmacogenetic studies: a) testing for interactions between candidate genes and hormone therapy using DNA samples from the participants in the Women's Health Initiative, and b) candidate gene and genome-wide scan approaches for determining genes that regulate the platelet response to aspirin.

Publications

Most Recent Peer-Reviewed Publications

  1. TULA-2 (T-Cell Ubiquitin Ligand-2) Inhibits the Platelet Fc Receptor for IgG IIA (FcγRIIA) Signaling Pathway and Heparin-Induced Thrombocytopenia in Mice
  2. Personalized medicine in thrombosis: Back to the future
  3. Integrative Multi-omic Analysis of Human Platelet eQTLs Reveals Alternative Start Site in Mitofusin 2
  4. Protease receptor antagonism to target blood platelet therapies
  5. A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders
  6. Anti-miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice
  7. Genome-wide association study of platelet aggregation in African Americans
  8. Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race
  9. MicroRNA expression differences in human hematopoietic cell lineages enable regulated transgene expression
  10. Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics
  11. The human platelet: Strong transcriptome correlations among individuals associate weakly with the platelet proteome
  12. PDK1 selectively phosphorylates Thr(308) on Akt and contributes to human platelet functional responses
  13. Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c
  14. Dengue platelets meet sir arthur conan doyle
  15. MicroRNAs in Platelet Production and Activation
  16. Platelet Genomics
  17. Erosive Arthritis and Hepatic Granuloma Formation Induced by Peptidoglycan Polysaccharide in Rats Is Aggravated by Prasugrel Treatment
  18. MicroRNAs in platelet production and activation
  19. The complex transcriptional landscape of the anucleate human platelet
  20. Small RNAs as potential platelet therapeutics