David Abraham, PhD
Philadelphia, PA 19107
(215) 923-9248 fax
Research and Clinical Interests
Role of eosinophils, neutrophils and macrophages in innate and adaptive immunity to nematode infections. The goal of these studies is to define at a molecular level the mechanisms used by these cells, from both humans and mice, to kill parasites and to identify the immune evasion mechanisms used by the parasites
Vaccine development against parasitic helminths. Multivalent vaccines are being developed against Onchocerca volvulus, the causative agent of river blindness, and against Stongyloides stercoralis. The basis of the vaccines will the combination of recombinant antigens with adjuvants capable of inducing specific types of immune responses.
Most Recent Peer-Reviewed Publications
- IL-12 eliminates the Th-2 dependent protective immune response of mice to larval Strongyloides stercoralis
- Structural and molecular specificity of antibody responses in mice immune to third stage larvae of Onchocerca volvulus
- Active and passive immunization of mice against larval Dirofilaria immitis
- In vitro culture of Dirofilaria immitis third- and fourth-stage larvae under defined conditions.
- Transplantation of adult Dirofilaria immitis into Lewis rats: Parasitologic and serologic findings
- In vitro cultivation of third-stage larvae of Litomosoides carinii to the fourth stage