Stephen R. Dunn

Assistant Professor of Medicine

Research and Clinical Interests:
Biomarkers, surrogate endpoints, Luminex, DNA isolation, Robotics, SNP analysis, allele discrimination assays, methods development in chromatography (HPLC and gas) ELISA, liquid handling automation, carcinogenesis, nitroso compounds, renal physiology, phenotyping of mouse models in diabetes, renal disease, probiotics.

215 503-6951
215-503-9142 FAX

Office Address
1009 Bluemle Life Science Building
233 South 10th St., Philadelphia, PA 19107

Email Address

BS Chemistry, ACS certified, May 1970
Rutgers Univ., Camden and New Brunswick, NJ

Graduate education:
St. Josephs Univ., Philadelphia, PA (Organic Anal Chem)
Temple Univ., Philadelphia, PA (Anal Chem)
Thomas Jefferson Univ., Philadelphia, PA (Molecular Biol and Statistics)

University Appointments:
1971-1993 Research Associate
1993-2002 Instructor in Medicine
2002-present Assistant Professor of Medicine

Publications List:

PubMed Link For Dunn SR

Hann HW L, Dunn SR, Ahn M, ParkSY. A single center open-label, randomized study comparing the safety of direct switching from lamivudine to adefovir Dipivoxil versus overlapping lamivudine and adefovir for three months before instituting adefovir monotherapy in patients with chronic hepatitis B. Hepatology International submitted

RamachandraRao SP, Zhu Y, Ravasi T, McGowan TA, Toh I, Dunn SR, Okada S, Shaw AM, Sharma K. Pirfenidone Is Renoprotective in Diabetic Kidney Disease.J Am Soc Nephrol, July 2, as doi: 10.1681/ASN.2008090931 2009.

Khazaei M, Moien-afshari F, Dunn SR, McCue, P, Sharma, K, Laher, I: The effect of low and moderate exercise on diabetic nephropathy in mouse model of type 2 diabetes. Am J Physiol-Renal 296:700-709, 2009.

Tchekneva EE, Khuchua Z, Davis LS, Kadkina V, Dunn SR, Bachman S, Ishibashi K, Rinchik EM, Harris RC, Dikov MM, Breyer MD: Single amino acid substitution in aquaporin 11 causes renal failure. J Am Soc Nephrol 19:1955-1964, 2008.

Pearson KJ, Baur JA, Lewis KN, Price NL, Minor R, Perez E, Kamara D, Jamieson HA, Zhang Y, Peshkin L, Dunn SR, Sharma K, Pleshko N, Woollett L, Labinskyy N, Csiszar A, Ikeno Y, Le Couteur D, Becker KG, Navas P, Ingram DK, Wolf N, Ungvari Z, Sinclair DA, de Cabo R: Resveratrol mimics aspects of dietary restriction and delays diseases of aging in mice. Cell Metabolism 8:1-12, 2008.

Srichai MB. Hao C. Davis L. Golovin A. Zhao M. Moeckel G. Dunn SR. Bulus N. Harris RC. Zent R. Breyer MD: Apoptosis of the thick ascending limb results in acute kidney injury. J Amer Soc Nephrol. 19:1538-1546, 2008.

Hann H-W, Chae HB, Dunn SR: Tenofovir (TDF) has stronger antiviral effect than adefovir (ADV) against lamivudine (LAM) resistant hepatitis B virus (HBV). Hepatology International 2:244-249, 2008

Sharma K, RamachandraRao S, Qiu G, Kataoka UH, Zhu Y, Dunn SR, Ouedraogo R, Hough K, McCue P, Chan L, Falkner B, Goldstein BJ: Adiponectin regulates albuminuria and podocyte function in mice. J Clin Invest. 118: 1645-1655, 2008.

Williams KJ, Qiu G, Usui HK, Dunn SR, McCue P, Böttinger E, Iozzo RV, Sharma K: Decorin deficiency causes an advanced and lethal nephropathy in diabetic mice. Am J Pathol.;171:1441-1450, 2007.

Gaughan WJ, Dunn SR, McGrory CH, Coscia LA, Moritz, Davison JM, Armenti VT: Relationship Between the Transplant-to-Conception Interval and Pregnancy Outcomes in Cyclosporine-Treated Female Kidney Recipients. Transplantation – a second look. Clin Nephrol 62:103-105, 2007.

Tchekneva EE. Rinchik EM. Polosukhina D. Davis LS. Kadkina V. Mohamed Y. Dunn SR. Sharma K. Qi Z. Fogo AB. Breyer MD: A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy. J Amer Soc Nephrol. 18:103-12, 2007.

Wang L, Flannery PJ, Athirakul K, Dunn SR, Kournay WM, Spurney: Gaq-Dependent signaling cascades stimulate water seeking behavior. Amer J Physiology-Renal 291: F781-F789, 2006.

Ranganathan N, Patel BG, Ranganathan P, Marczely J, Dheer R, Pechenyak B, Dunn SR, Verstraete W, Decroos K, Mehta R, Friedman EA: In vitro and in vivo assessment of intra-intestinal bacteriotherapy in chronic kidney disease. Transactions-American Society for Artificial Internal Organs 52:70-9. 2006.

Gaughan WJ, Dunn, SR, McGrory CH, Cosica LA, Moritz, MJ, Davison, JM, Armenti VT: Relationship between the transplant-to-conception interval and pregnancy outcomes in cyclosporine treated female kidney recipients. Clin Nephrol 61:126-130, 2006.

McGowan TA, Dunn SR, Falkner B, Sharma K: Stimulation of Urinary TGF-beta and Isoprostanes in Response to Hyperglycemia in Humans. Clin J Am Soc Nephrol: 263-268, 2006.

Ranganathan N, Patel B, Ranganathan, P, Marczely, J, Dheer R., Chordia T, Dunn SR., Friedman EA: Probiotic amelioration of azotemia in 5/6th nephrectomized Sprague Dawley rats. The Scientific World J 5:652-660, 2005.

De Godoy M, Dunn SR, Rattan S: Evidence for the role of angiotensin II biosynthesis in the rat internal anal sphincter tone. Gastroenterology 127:127-138, 2004.

Dunn SR, Qi Z, Böttinger EP, Breyer MD, Sharma K.: Utility of endogenous creatinine clearance as a measure of renal function in mice. Kidney International 65:1959-1967, 2004.

Susztak K, Böttinger E, Novetsky A, Liang D, Zhu Y, Ciccione E, Wu D, Dunn S, McCue P, Sharma K: Molecular profiling of diabetic mouse kidneys reveals novel genes linked to glomerular disease. Diabetes 53:784-794, 2004.

Yuen PST, Dunn SR, Miyaji T, Sharma K, Star RA: A Simplified Method for HPLC Determination of Creatinine in Mouse Serum. Amer J Physiol-Renal 286:F1116-F1119, 200.4

Tsuchida K-I, Zhu Y, Siva S, Dunn SR, Sharma K: Role of Smad4 on TGF-beta-induced extracellular matrix stimulation in mesangial cells. Kidney International 63:2000-2009, 2003.

Sharma K, McCue P, Dunn SR: Diabetic kidney disease in the db/db mouse. Invited Review. Amer J. Physiology 284:F1138-F1144, 2003.

Herrine SK, Michael B, Ma WL, Rossi S, Dunn SR, Hyslop T: Development of a Hepatitis C Virus (HCV) Infection Risk Stratification Algorithm for Patients on Chronic Hemodialysis. Amer J Gastroenterology 97:2619-2622 2002

McGory CH, McCloskey LJ, DeHoratius RJ, Dunn SR, Moritz MJ, Armenti VT. Pregnancy outcomes in female renal recipients: Comparison of SLE to other diagnoses Amer  J Transplantation 3: 35-42, 2003.

Agarwal R., Siva, S., Dunn S., Sharma K: Effect of add-on angiotensin II receptor blockade on urinary transforming growth factor-beta levels. Amer J Kidney Diseases 39:486-492, 2002.

Gaughan W, Fels EJ, Leone FT, McGowan T, Dunn SR, Smith J, Burke JF. The initial attitudes of patients toward longer maintenance hemodialysis. Clin Nephrol 56:150-154, 2001.

Viswanathan V, Y Zhu, Bala K, Dunn S, Snehalatha C, Ramachandran A, Jayarama M, Sharma K: Association between ACE Gene Polymorphism and DiabeticNephropathy in South Indian Patients. J. Pancreas (Online); 2:000-000.(Electronic) 2001.

Wilson GA, Cosicia LA, McGory CH, Dunn SR, Radomski JS, Moritz MJ, Armenti VT: National transplant pregnancy registry: Post pregnancy graft loss among female pancreas-kidney recipients. Transplantation Proc 33:1667-1669, 2001.

Islam M, Burke JF Jr, McGowan TA, Zhu Y, Dunn, SR, McCue, P, Kanalas, Sharma K: Effect of anti-TGF-beta antibodies in cyclosporine-induced renal dysfunction. Kidney International 59:498-505, 2001.

Sharma K, Eltayeb BO, McGowan TA, Dunn SR, Alzahabi B, Rohde R, Ziyadeh FN, Lewis EJ: Captopril induced reduction of serum levels of transforming growth factor-beta1 predicts long-term reno-protection in insulin-dependent diabetic patients. Amer J Kidney Disease 34:818-823, 1999.

Dunn SR, Simenhoff ML, Ahmed KE, Gaughan WJ, Eltayeb BO, Fitzpatrick ME, Emery, SM, Ayres JW. Holt KR: Effect of oral administration of freeze-dried lactobacillus acidophilus on small bowel bacterial overgrowth in patients with end stage kidney disease: reducing uremic toxins and improving nutrition. International Dairy J 8:545-553, 1998.

Islam MS, Francos GC, Dunn SR, Burke JF: Mycophenolate mofetil and reduction in cyclosporine dosage for chronic renal allograft dysfunction. Transplantation Proc. 30:2230-2231, 1998.

Gaughan WJ, Liss K, Dunn SR, Mangold, AM, Bushmer JP, Michael B, Burke JF: A 6 month study of very low dose recombinant human erythropoietin alone and with androgen for the treatment of anemia in chronic hemodialysis patients. Amer J Kid Dis 30:495-500, 1997.

Sharma K, Considine R, Michael B, Dunn SR, Weisberg L, Kurnik B, Kurnik P, O’Connor J, Sinha M, Caro JF: Plasma Leptin is partly cleaved by the kidney and is elevated in hemodialysis patients. Kidney International 51:1980-1995, 1997.

Dunn SR, Gabuzda GM, Superdock KR, Kolecki RS, Schaedler RW, Simenhoff ML, Induction of creatininase activity in chronic renal failure: timing of creatinine degradation and effect of antibiotics. Amer J Kidney Disease 27:72-77, 1997.

Simenhoff ML, Dunn SR, Zollner GP, Fitzpatrick M-E, Emery SM, Sandine WE, Ayres JW: Biomodulation of the toxic and nutritional effects of small bowel bacterial overgrowth (SBBO) in end stage kidney disease (ESKD) using freeze-dried L Acidophilus (LBA). Mineral & Electrolyte Metabolism 22:92-96, 1996.

Simenhoff ML, Dunn SR: Altered gut flora in uremia. J Renal Nutrition 6:68-74, 1996.

Gaughan WJ, Francos BB, Dunn SR, Francos GC, Burke JF: A retrospective analysis of the effect of indomethacin on adverse reactions to orthoclone OKT3 in the therapy of acute renal allograft rejection. Amer J Kidney Disease 24:486-490, 1994.

Simenhoff ML, Dunn SR, Ayers, JW, Lin, SY, Sandine, WE, Coar, DN: Reduction of intestinal N-nitrosodimethylamine (NDMA) and its endogenous precursor formation in a model of patients with chronic renal failure treated with human strain of freeze-dried, enteric coated Lactobacillus acidophilus. Nitroso Compounds: Biological Mechanisms, Exposures and Cancer Etiology. In: International Agency for Research on Cancer, Technical Report 11, Lyon (I.K. O’Neil & H. Bartsch eds.). IARC Conference Proceedings, Kailua-Kona, Hawaii, Nov 1- 2, O15-16 1991.

Dunn SR, Simenhoff ML, Lele, PS, Goyal S, Pensabene JW, Fiddler W: N-Nitrosodimethylamine blood levels in patients with chronic renal failure: modulation of levels by ethanol and ascorbic acid. J Nat Cancer Inst 82:783-787, 1990.

Lele PS, Dunn SR, Simenhoff ML: Nutritional and metabolic modulation of the carcinogen, nitrosodimethylamine, in chronic renal failure. Kidney International 32:S159-S161, 1987.

Dunn SR, Pensabene JW, Simenhoff M: Analysis of human blood for volatile N-nitrosamines by gas chromatography-chemiluminescence detection. J. Chromatog 377:35-47, 1986.

Simenhoff ML, Dunn SR, Lele PS: Analysis for and intestinal metabolism of precursor N-nitroso compounds in normal subjects and patients with chronic renal failure. In: N-Nitroso Compounds: Occurrence, Biological Effects and Relevance to Human Cancer, IARC Scientific Publication 57:161-170, 1984.

Ihle BU, Cox RW, Dunn SR, Simenhoff ML: Determination of body burden of uremic toxins. Clin Nephrol 22:82-89, 1984.

Lele PS, Dunn SR, Simenhoff ML, Fiddler W, Pensabene JW: Evidence for generation of the precarcinogen, nitrosodimethylamine, in the small intestine in chronic renal failure. Kidney International 24:229-233, 1983.

Simenhoff ML, Dunn SR, Smiley JW: Generation of the carcinogen dimethylnitrosamine in water purification systems: Detection in human blood samples during hemodialysis. J Amer Med Assoc 250:2020-2024, 1983.

Kirkwood RG, Dunn SR, Thomasson L. Simenhoff ML: Generation of the precarcinogen dimethylnitrosamine (DMNA) in dialysate water. Transactions-American Society for Artificial Internal Organs. 27:168-71, 1981.

Lakritz L, Simenhoff ML, Dunn SR, Fiddler W: N-nitrosodimethylamine in human blood. Food Cosmet Toxicol, 18 77-80, 1980.

Wesson LG, Colberg JE, Deguzman A, Elsasser W, Dunn SR: Extracellular fluid of the kidney preserved by the Collins technique. Transplantation 27, 380-383, 1979.

Dunn SR, Simenhoff ML,Wesson LG: Gas chromatographic determination of mono-, di- and trimethylamines in biological fluids. Anaytical Chem 48, 41-44, 1976.

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