Sankar Addya, Ph.D.

Cancer Genomics Specialist

Kimmel Cancer Center

Research Interests:
Hematopoietic stem cells and genomic research

215-503-9142 FAX

Office Address
1009 Bluemle Life Science Building
233 South 10th St. , Philadelphia, PA 19107

Email Address

B.S. in Chemistry, Calcutta University, Calcutta, India (1978)
M.S. in Biochemistry, Calcutta University, Calcutta, India (1981)
Ph.D. in Biochemistry, Calcutta University, Calcutta, India (1989)

Post Doctoral Fellowship
University of Pennsylvania, Philadelphia (1988-1991)

Certifications / Diploma / Training
Diploma in Client/Server Programming (1997-99): Computer Learning Center, Philadelphia
Information Systems in Organization (2001): Thomas Jefferson University, Philadelphia
Basic Gene Mapping/ Linkage Course (2008): Rockefeller University, New York
Training in GeneSpring 10.0 (2008): Agilent Technologies, USA
Training in GeneSpring 11.0 (2009): Agilent Technologies, USA

University Appointment
Research Associate (1992-1999): University of Pennsylvania, Philadelphia
Research Associate (2001-2007): Thomas Jefferson University, Philadelphia
Cancer Genomics Specialist (2007- present): Kimmel Cancer Center, Thomas Jefferson University, Philadelphia

Hospital Appointment
Research Assistant II (1999-2000): DuPont Hospital for Children, Wilmington

Research & Clinical Interest:
I have been working on different research projects involved in hematopoietic stem cells and genomic research with the hematology group of Thomas Jefferson University and I have developed skills in hematopoietic stem cells culture from adult and cord blood. In my research studies, I am using an in vitro erythroid differentiation system to identify regulatory molecules critical to fetal hemoglobin gene expression using genome-wide microarray based expression profiling of primary erythroid progenitors derived from human cord blood vs adult blood hematopoietic progenitor cells. I have had extensive training in micro-array experiments and statistical analysis for micro-array data. I have collaborates on different genomics projects in Jefferson as well as University of Connecticut Health Center. My goal is to apply my research experience to genomics research.

Publications List:

PubMed Link For Addya S

Augustus AS, Buchanan J, Addya S, Rengo G, Pestell RG, Fortina P, Koch WJ, Bensadoun A, Abel ED, Lisanti MP. Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts. Am J Physiol Heart Circ Physiol. 295(2):H657-66, 2008

Thirunavukkarasu M, Addya S, Juhasz B, Pant R, Zhan L, Surrey S, Maulik G, Menon VP, Maulik N. Heterozygous disruption of Flk-1 receptor leads to myocardial ischaemia reperfusion injury in mice: application of affymetrix gene chip analysis. J Cell Mol Med. 12(4):1284-302, 2008

Keller MA, Addya S, Vadigepalli R, Banini B, Delgrosso K, Huang H, Surrey S Transcriptional regulatory network analysis of developing human erythroid progenitors reveals patterns of coregulation and potential transcriptional regulators. Physiol Genomics 13: 28(1):114-28, 2006

Sarkar R, Mucci M, Addya S, Tetreault R, Bellinger DA, Nichols TC, Kazazian HH Jr. Long-term efficacy of adeno-associated virus serotypes 8 and 9 in hemophilia a dogs and mice. Hum Gene Ther 17: 427-39, 2006

Chen W, Tang Z, Fortina P, Patel, P, Addya S, Surrey S, Acheampong EA, Mukhtar M, Pomerantz RJ. Ethanol potentiates HIV-1 gp120-induced apoptosis in human neurons via both the death receptor and NMDA receptor pathways. Virology 334: 59-73, 2005

Addya S, Shiroto K, Turoczi T, Zhan L, Kaga S, Fukuda S, Surrey S, Duan LJ, Fong GH, Yamamoto F, Maulik N. Ischemic preconditioning-mediated cardioprotection is disrupted in heterozygous Flt-1 (VEGFR-1) knockout mice. Mol. Cell. Cardiol. 38: 345-51, 2005

Addya S, Keller MA, Delgrosso K, Ponte CM, Vadigepalli R, Gonye GE, Surrey S. Erythroid-induced commitment of K562 cells results in clusters of differentially expressed genes enriched for specific transcription regulatory elements. Physiol Genomics. 19: 117-30, 2004

Tang Z, McGowan BS, Huber SA., McTiernan, CF, Addya S, Surrey S, Kubota T, Fortina P., Higuchi Y, Diamond MA, Wyre DS, Feldman AM. Gene expression profiling during the transition to failure in TNF-alpha over-expressing mice demonstrates the development of autoimmune myocarditis. J. Mol. Cell. Cardiol. 36:515-30. 2004

Graves DJ, Su HJ, Addya S, Surrey S, Fortina, P. Four-laser scanning confocal system for microarray analysis. Biotechniques 32:346-8, 2002

Maulik N, Sasaki H, Addya S, Das DK. Regulation of cardiomyocyte apoptosis by redox-sensitive transcription factors. FEBS Lett. 485:7-12, 2000

Sinha D, Addya S, Murer E, Borden G. 15-Deoxy-delta(12,14) prostaglandin J2: a putative endogenous promoter of adipogenesis suppresses the ob gene. Metabolism 48: 786-91, 1999

Anandatheerthavarada HK, Addya S, Mullick J, Avadhani NG. Interaction of Adrenodoxin with P4501A1 and its trancated form P450MT2 through different domains: differential modulation of enzyme activities. Biochemistry 37: 1150-1160, 1998

Addya S, Anandatheerthavarada HK, Biswas G, Bhagwat SV, Mullick J, Avadhani NG. Targeting of N-terminal processed Microsomal protein to mitochondria: A novel Pathway for the biogenesis of hepatic mitochondrial P450MT2. J. Cell Biol. 139: 589-599, 1997

Anandatheerthavarada HK, Addya S, Dwivedi RS, Biswas G, Mullick J, Avadhani NG. Localization of multiple forms of inducible cytochromes P450 in rat liver mitochondria:Immunological characteristics and patterns of xenobiotic substrate metabolism. Arch. Biochem. Biophys. 339: 136-150, 1997

Mullick J, Addya S, Sucharov C, Avadhani NG. Localization of a transcription promotor within the second exon of the cytochrome P-450c27/25 gene for the expression of the major species of two-kilobase mRNA. Biochemistry 34: 13729, 1995

Addya S, Mullick J, Fang J, Avadhani NG. Purification and characterization of a hepatic mitochondrial glutathione S-transferase exhibiting immunochemical relationship to the -class of cytosolic isozymes. Arch. Biochem. Biophys. 310: 82, 1994

Addya S, Zheng Y, Shayiq RM, Fan J, Avadhani NG. Characterization of a female-specific hepatic mitochondrial cytochrome P450 whose steady-state level is modulated by testosterone. Biochemistry. 30: 8323, 1991

Shayiq RM, Addya S, Avadhani NG. The constitutive and inducible forms of cytochrome P450 from hepatic mitochondria. Methods in Enzymol. 206: 587, 1991

Su P, Rennert H, Shayiq RM, Yamamoto R, Zheng Y, Addya S, StraussIII JM, Avadhani NG. A cDNA encoding a rat mitochondrial cytochrome P450 catalysing both the 26 hydroxylation of cholesterol and 25 hydroxylation of Vitamin D3: Gonadotropic regulation of the cognate mRNA in ovaries. DNA and Cell Biol. 9: 657, 1990

Mukhopadhyay S, Mukhopadhyay S, Addya S, Bhattacharya DK, Chatterjee GC. Effects of cadmium treatment in vitro on the uptake and release of 3H serotonin of human blood platelets. Indian J. Biochem. Biophys. 26: 56, 1989

Mukhopadhyay S, Mukhopadhyay S, Addya S, Bhattacharya DK, Chatterjee GC. Effects of cadmium treatment in vitro on the antioxidant protection mechanism and activation of human blood platetets. Thombosis Research. 50: 419, 1988

Mukhopadhyay S, Mukhopadhyay S, Addya S, Bhattacharya DK, Chatterjee GC. Interaction of lanthanum and calcium ions during uptake and release of serotonin by human blood platelets in vitro. Indian J. Biochem. Biophys. 25: 257, 1988

Chattopadhyay D, Mukhopadhyay S, Ghosh N, Addya S, Chatterjee GC. Effect of oral cadmium adminstration on several glutathione cycle enzymes and a few membrane bound enzymes of intestinal epithelial cells in rats. Indian J. Biochem. Biophys. 24: 234, 1987

Santra M, Basu A, Addya S, Ray MK, Chatterjee GC. Studies on the characteristics of liver and spleen ferritin under lead toxicity in rats. Indian J. Biochem. Biophys. 23: 291, 1986

Addya S, Chakravorti K, Das M, Ghosh N, Chakravorti D, Chatterjee GC. Effects of mercuric chloride on the antioxidant defence componants of rat erythrocyte and plasma: Influence of Vitamin E supplimentation. Indian J. Exp. Biol. 24: 468, 1986

Basu A, Chakravarti K, Haldar S, Addya S, Chatterjee GC. The effects of lanthanum chloride administration in new born chicks on glutamate uptake and release by brain synaptosomes. Toxicol. Lett. 20: 303, 1984

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