Hallgeir Rui, M.D., Ph.D.

Cancer Biology


Office Address
332 BLSB
233 S. 10th St.

Email Address


MD, University of Oslo, Norway - 1980-1987
PhD, Pathology, University of Oslo, Norway - 1983-1988

Expertise & Research Interests
Dr. Rui has made a series of contributions to increased understanding of the molecular mechanisms of signal transduction by receptors for prolactin and related cytokines and hormones. Dr. Rui was the first to isolate a prolactin  receptor-associated tyrosine kinase, and to identify this molecule as Janus kinase-2. Dr. Rui's laboratory has maintained a focus on prolactin receptor function with a primary goal of understanding the role of  downstream Jak-Stat pathways and their aberrations in breast cancer.

Activation of Stat5 is a strong favorable prognostic marker in breast cancer and an invasion-suppressive role of Stat5 in human breast cancer may represent a biological mechanism. Loss of Stat5 is further associated with increased risk of antiestrogen resistance. Dr. Rui and his team have also invented and applied a new technology to generate  high density tumor tissue arrays for high-through-put molecular  profiling. Dr. Rui is the PI of a $6.7 million, 5 year Komen Promise  Grant to a consortium of multidisciplinary investigators to classify malignant breast tumors based on expression of druggable target proteins for improved personalized cancer care. The consortium project also involves a novel Bayesian adaptive biomarker-centered Phase II clinical trial of a Parp-inhibitor in the neoadjuvant setting for triple-negative breast cancer.

Cancer Biology Profile            Google Scholar   

Keywords: cancer; breast cancer; hormone; endocrinology; prolactin; growth hormone; estrogen; glucocorticoid; steroid hormones; Jak2; Stat5; Stat5a; Stat5b; immunohistochemistry; pathology; biomarker; early detection; microarray; tissue microarray; mouse modeling; EGFR; Her2; ErbB2; prolactin receptor;

PubMed Link For Rui H


Web page revised: June 03, 2015.
URL: http://www.kimmelcancercenter.org/kcc/kccnew/staff/staffdefault.php

NCI Designated Cancer Center

Maintained by the Informatics Shared Resources of the Sidney Kimmel Cancer Center at Jefferson

Copyright © Thomas Jefferson University. All Rights Reserved.

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement