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| My research focuses on the type 1 insulin-like growth factor receptor (IGF-IR), a receptor that plays important roles in the growth, differentiation and malignant transformation of cells. Like all growth factor receptors, it is activated by ligands, in this case, three ligands, IGF-I, IGF-II and insulin. When activated, the IGF-IR also sends a strong anti-apoptotic signal. As a corollary, down-regulation of the IGF-IR leads to massive apoptosis, especially of tumor cells. Several patents on targeting of the IGF-IR have been filed by Thomas Jefferson University and my group, and two of these patents are developed by biotech and pharmaceutical companies. In the laboratory, the present interests deal with signal transduction from the IGF-IR and the mechanism by which it activates arious genetic programs in the cell. Keywords: Aging; Biochemistry; Biological Signal Transduction; Biomedical Facility; Biophysics; Cell Biology; Cell Cycle Protein; Cell Differentiation; Cell Growth Regulation; Cell Senescence; Complementary Dna; Developmental Biology; Developmental Neurobiology; Diploidy; Dna Binding Protein; Dna Replication; Epidermal Growth Factor; Ethanol; Fibroblast; Gel Electrophoresis; Gene Expression; Genetic Mapping; Genetic Promoter Element; Genetic Regulation; Genetic Regulatory Element; Genetic Transcription; Genetics; Growth Factor Receptor; Growth Inhibitor; Human Physiology; Immortalized Cell; Insulinlike Growth Factor; Messenger Rna; Microinjection; Mitogen; Molecular Biology; Molecular Cloning; Molecular Genetics; Molecular Site; Northern Blotting; Nuclear Runoff Assay; Nucleic Acid Sequence; Oncogene; Pharmacology; Platelet Derived Growth Factor; Polymerase Chain Reaction; Proliferating Cell Nuclear Antigen; Protein Biosynthesis; Protein Purification; Protein Sequence; Protooncogene; Receptor Binding; Receptor Expression; Simian Virus; Structural Gene; Temperature Sensitive Mutant; Tissue Cell Culture; Transcription Factor; Transfection; Virus Antigen | ||||
| Selected Publications Maiorana A, Tu X, Cheng G, Baserga R. Role of pescadillo in the transformation and immortalization of mammalia cells. Oncogene 2004 Jul 26;. ( Abstract ) Drakas R, Tu X, Baserga R. Control of cell size through phosphorylation of upstream binding factor 1 by nuclear phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A 2004 Jun 22;101(25):9272-6. Epub 2004 Jun 14.. ( Abstract ) Tu X, Wu A, Maiorana A, Baserga R. Subcellular Localization of IRS-1 in Cell Proliferation an Differentiation. Horm Metab Res 2004 Jan;36(1):72. ( Abstract ) Tu X, Wu A, Maiorana A, Baserga R. Subcellular localization of IRS-1 in cell proliferation and differentiation. Horm Metab Res 2003 Nov-Dec;35(11-12):734-9.. ( Abstract ) Baserga R, Peruzzi F, Reiss K. The IGF-1 receptor in cancer biology. Int J Cancer 2003 Dec 20;107(6):873-7. ( Abstract ) Tu X, Baffa R, Luke S, Prisco M, Baserga R. Intracellular redistribution of nuclear and nucleolar proteins during differentiation of 32D murine hemopoietic cells. Exp Cell Res 2003 Aug 1;288(1):119-30.. ( Abstract ) Sciacca L, Prisco M, Wu A, Belfiore A, Vigneri R, Baserga R. Signaling differences from the A and B isoforms of the insulin recepto (IR) in 32D cells in the presence or absence of IR substrate-1. Endocrinology 2003 Jun;144(6):2650-8. ( Abstract ) Wu A, Sciacca L, Baserga R. Nuclear translocation of insulin receptor substrate-1 by the insulin receptor in mouse embryo fibroblasts. J Cell Physiol 2003 Jun;195(3):453-60.. ( Abstract ) Sun H, Tu X, Prisco M, Wu A, Casiburi I, Baserga R. Insulin-like growth factor I receptor signaling and nuclear translocatio of insulin receptor substrates 1 and 2. Mol Endocrinol 2003 Mar;17(3):472-86. Epub 2002 Dec 6. ( Abstract ) Tu X, Batta P, Innocent N, Prisco M, Casaburi I, Belletti B, Baserga R. Nuclear translocation of insulin receptor substrate-1 by oncogenes an Igf-I. Effect on ribosomal RNA synthesis. J Biol Chem 2002 Nov 15;277(46):44357-65. Epub 2002 Aug 28. ( Abstract ) Peretz S, Kim C, Rockwell S, Baserga R, Glazer PM. IGF1 receptor expression protects against microenvironmental stress found in the solid tumor. Radiat Res 2002 Aug;158(2):174-80.. ( Abstract ) Prisco M, Santini F, Baffa R, Liu M, Drakas R, Wu A, Baserga R. Nuclear translocation of insulin receptor substrate-1 by the simian viru 40 T antigen and the activated type 1 insulin-like growth factor receptor. J Biol Chem 2002 Aug 30;277(35):32078-85. Epub 2002 Jun 12. ( Abstract ) Belletti B, Drakas R, Morrione A, Tu X, Prisco M, Yuan T, Casaburi I, Baserga R. Regulation of Id1 protein expression in mouse embryo fibroblasts by the type 1 insulin-like growth factor receptor. Exp Cell Res 2002 Jul 1;277(1):107-18.. ( Abstract ) Navarro M, Valentinis B, Belletti B, Romano G, Reiss K, Baserga R. Regulation of Id2 gene expression by the type 1 IGF receptor and the insulin receptor substrate-1. Endocrinology 2001 Dec;142(12):5149-57.. ( Abstract ) Morrione A, Navarro M, Romano G, Dews M, Reiss K, Valentinis B, Belletti B, Baserga R. The role of the insulin receptor substrate-1 in the differentiation of rat hippocampal neuronal cells. Oncogene 2001 Aug 9;20(35):4842-52.. ( Abstract ) Prisco M, Peruzzi F, Belletti B, Baserga R. Regulation of Id gene expression by type I insulin-like growth factor roles of Stat3 and the tyrosine 950 residue of the receptor. Mol Cell Biol 2001 Aug;21(16):5447-58. ( Abstract ) Reiss K, Tu X, Romano G, Peruzzi F, Wang JY, Baserga R. Intracellular association of a mutant insulin-like growth factor receptor with endogenous receptors. Clin Cancer Res 2001 Jul;7(7):2134-44.. ( Abstract ) Valentinis B, Baserga R. IGF-I receptor signalling in transformation and differentiation. Mol Pathol 2001 Jun;54(3):133-7.. ( Abstract ) Peruzzi F, Prisco M, Morrione A, Valentinis B, Baserga R. Anti-apoptotic signaling of the insulin-like growth factor-I receptor through mitochondrial translocation of c-Raf and Nedd4. J Biol Chem 2001 Jul 13;276(28):25990-6. Epub 2001 May 14.. ( Abstract ) | ||||
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