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Home » Research Small Molecule Screening Resource
The small molecule screening resource consists of liquid handling and multiwell detection instrumentation to facilitate high throughput screening of compound collections for the discovery of small molecule effectors of biological targets. The resource includes a Matrix technologies Hydra II + 1 low volume liquid handler, a Biomek 2000 arraying robot housed in a Baker SG-603a reinforced biosafety cabinet and a BMG POLARstar Optima multifunction plate reader (UV/vis, fluorescence intensity, fluorescence anisotropy, time-resolved fluorescence & luminescence). The compound collection is currently being assembled from commercially-available plated screening sets. In addition, resource equipment can be used by KCC members to array sources of molecular diversity that they obtain independently (for example, plated screening sets from the Developmental Therapeutics Program of the National Cancer Institute).
Contact Michael Watson (3-4587) or Dr. Scott (3-4569) to obtain arrayed compounds, arrange for training or consult on assay design. |
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