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| Education: B.S. in Chemistry, Calcutta University, Calcutta, India (1978) M.S. in Biochemistry, Calcutta University, Calcutta, India (1981) Ph.D. in Biochemistry, Calcutta University, Calcutta, India (1989) Post Doctoral Fellowship University of Pennsylvania, Philadelphia (1988-1991) Certifications / Diploma / Training Diploma in Client/Server Programming (1997-99): Computer Learning Center, Philadelphia Information Systems in Organization (2001): Thomas Jefferson University, Philadelphia Basic Gene Mapping/ Linkage Course (2008): Rockefeller University, New York Training in GeneSpring 10.0 (2008): Agilent Technologies, USA Training in GeneSpring 11.0 (2009): Agilent Technologies, USA University Appointment Research Associate (1992-1999): University of Pennsylvania, Philadelphia Research Associate (2001-2007): Thomas Jefferson University, Philadelphia Cancer Genomics Specialist (2007- present): Kimmel Cancer Center, Thomas Jefferson University, Philadelphia Hospital Appointment Research Assistant II (1999-2000): DuPont Hospital for Children, Wilmington Research & Clinical Interest: I have been working on different research projects involved in hematopoietic stem cells and genomic research with the hematology group of Thomas Jefferson University and I have developed skills in hematopoietic stem cells culture from adult and cord blood. In my research studies, I am using an in vitro erythroid differentiation system to identify regulatory molecules critical to fetal hemoglobin gene expression using genome-wide microarray based expression profiling of primary erythroid progenitors derived from human cord blood vs adult blood hematopoietic progenitor cells. I have had extensive training in micro-array experiments and statistical analysis for micro-array data. I have collaborates on different genomics projects in Jefferson as well as University of Connecticut Health Center. My goal is to apply my research experience to genomics research. Keywords: |
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| Publications List: Augustus AS, Buchanan J, Addya S, Rengo G, Pestell RG, Fortina P, Koch WJ, Bensadoun A, Abel ED, Lisanti MP. Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts. Am J Physiol Heart Circ Physiol. 295(2):H657-66, 2008 Thirunavukkarasu M, Addya S, Juhasz B, Pant R, Zhan L, Surrey S, Maulik G, Menon VP, Maulik N. Heterozygous disruption of Flk-1 receptor leads to myocardial ischaemia reperfusion injury in mice: application of affymetrix gene chip analysis. J Cell Mol Med. 12(4):1284-302, 2008 Keller MA, Addya S, Vadigepalli R, Banini B, Delgrosso K, Huang H, Surrey S Transcriptional regulatory network analysis of developing human erythroid progenitors reveals patterns of coregulation and potential transcriptional regulators. Physiol Genomics 13: 28(1):114-28, 2006 Sarkar R, Mucci M, Addya S, Tetreault R, Bellinger DA, Nichols TC, Kazazian HH Jr. Long-term efficacy of adeno-associated virus serotypes 8 and 9 in hemophilia a dogs and mice. Hum Gene Ther 17: 427-39, 2006 Chen W, Tang Z, Fortina P, Patel, P, Addya S, Surrey S, Acheampong EA, Mukhtar M, Pomerantz RJ. Ethanol potentiates HIV-1 gp120-induced apoptosis in human neurons via both the death receptor and NMDA receptor pathways. Virology 334: 59-73, 2005 Addya S, Shiroto K, Turoczi T, Zhan L, Kaga S, Fukuda S, Surrey S, Duan LJ, Fong GH, Yamamoto F, Maulik N. Ischemic preconditioning-mediated cardioprotection is disrupted in heterozygous Flt-1 (VEGFR-1) knockout mice. Mol. Cell. Cardiol. 38: 345-51, 2005 Addya S, Keller MA, Delgrosso K, Ponte CM, Vadigepalli R, Gonye GE, Surrey S. Erythroid-induced commitment of K562 cells results in clusters of differentially expressed genes enriched for specific transcription regulatory elements. Physiol Genomics. 19: 117-30, 2004 Tang Z, McGowan BS, Huber SA., McTiernan, CF, Addya S, Surrey S, Kubota T, Fortina P., Higuchi Y, Diamond MA, Wyre DS, Feldman AM. Gene expression profiling during the transition to failure in TNF-alpha over-expressing mice demonstrates the development of autoimmune myocarditis. J. Mol. Cell. Cardiol. 36:515-30. 2004 Graves DJ, Su HJ, Addya S, Surrey S, Fortina, P. Four-laser scanning confocal system for microarray analysis. Biotechniques 32:346-8, 2002 Maulik N, Sasaki H, Addya S, Das DK. Regulation of cardiomyocyte apoptosis by redox-sensitive transcription factors. FEBS Lett. 485:7-12, 2000 Sinha D, Addya S, Murer E, Borden G. 15-Deoxy-delta(12,14) prostaglandin J2: a putative endogenous promoter of adipogenesis suppresses the ob gene. Metabolism 48: 786-91, 1999 Anandatheerthavarada HK, Addya S, Mullick J, Avadhani NG. Interaction of Adrenodoxin with P4501A1 and its trancated form P450MT2 through different domains: differential modulation of enzyme activities. Biochemistry 37: 1150-1160, 1998 Addya S, Anandatheerthavarada HK, Biswas G, Bhagwat SV, Mullick J, Avadhani NG. Targeting of N-terminal processed Microsomal protein to mitochondria: A novel Pathway for the biogenesis of hepatic mitochondrial P450MT2. J. Cell Biol. 139: 589-599, 1997 Anandatheerthavarada HK, Addya S, Dwivedi RS, Biswas G, Mullick J, Avadhani NG. Localization of multiple forms of inducible cytochromes P450 in rat liver mitochondria:Immunological characteristics and patterns of xenobiotic substrate metabolism. Arch. Biochem. Biophys. 339: 136-150, 1997 Mullick J, Addya S, Sucharov C, Avadhani NG. Localization of a transcription promotor within the second exon of the cytochrome P-450c27/25 gene for the expression of the major species of two-kilobase mRNA. Biochemistry 34: 13729, 1995 Addya S, Mullick J, Fang J, Avadhani NG. Purification and characterization of a hepatic mitochondrial glutathione S-transferase exhibiting immunochemical relationship to the -class of cytosolic isozymes. Arch. Biochem. Biophys. 310: 82, 1994 Addya S, Zheng Y, Shayiq RM, Fan J, Avadhani NG. Characterization of a female-specific hepatic mitochondrial cytochrome P450 whose steady-state level is modulated by testosterone. Biochemistry. 30: 8323, 1991 Shayiq RM, Addya S, Avadhani NG. The constitutive and inducible forms of cytochrome P450 from hepatic mitochondria. Methods in Enzymol. 206: 587, 1991 Su P, Rennert H, Shayiq RM, Yamamoto R, Zheng Y, Addya S, StraussIII JM, Avadhani NG. A cDNA encoding a rat mitochondrial cytochrome P450 catalysing both the 26 hydroxylation of cholesterol and 25 hydroxylation of Vitamin D3: Gonadotropic regulation of the cognate mRNA in ovaries. DNA and Cell Biol. 9: 657, 1990 Mukhopadhyay S, Mukhopadhyay S, Addya S, Bhattacharya DK, Chatterjee GC. Effects of cadmium treatment in vitro on the uptake and release of 3H serotonin of human blood platelets. Indian J. Biochem. Biophys. 26: 56, 1989 Mukhopadhyay S, Mukhopadhyay S, Addya S, Bhattacharya DK, Chatterjee GC. Effects of cadmium treatment in vitro on the antioxidant protection mechanism and activation of human blood platetets. Thombosis Research. 50: 419, 1988 Mukhopadhyay S, Mukhopadhyay S, Addya S, Bhattacharya DK, Chatterjee GC. Interaction of lanthanum and calcium ions during uptake and release of serotonin by human blood platelets in vitro. Indian J. Biochem. Biophys. 25: 257, 1988 Chattopadhyay D, Mukhopadhyay S, Ghosh N, Addya S, Chatterjee GC. Effect of oral cadmium adminstration on several glutathione cycle enzymes and a few membrane bound enzymes of intestinal epithelial cells in rats. Indian J. Biochem. Biophys. 24: 234, 1987 Santra M, Basu A, Addya S, Ray MK, Chatterjee GC. Studies on the characteristics of liver and spleen ferritin under lead toxicity in rats. Indian J. Biochem. Biophys. 23: 291, 1986 Addya S, Chakravorti K, Das M, Ghosh N, Chakravorti D, Chatterjee GC. Effects of mercuric chloride on the antioxidant defence componants of rat erythrocyte and plasma: Influence of Vitamin E supplimentation. Indian J. Exp. Biol. 24: 468, 1986 Basu A, Chakravarti K, Haldar S, Addya S, Chatterjee GC. The effects of lanthanum chloride administration in new born chicks on glutamate uptake and release by brain synaptosomes. Toxicol. Lett. 20: 303, 1984 |
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